Publications

Pubmed Bibliogrpahy URL.
https://www.ncbi.nlm.nih.gov/sites/myncbi/amy.medlock.1/bibliography/42526867/public/?sort=date&direction=descending

Martinez-Guzman O, Willoughby MM, Saini A, Dietz JV, Bohovych I, Medlock AE, Khalimonchuk O, Reddi AR. Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites. J Cell Sci. 2020 May 20;133(10). doi: 10.1242/jcs.237917. PubMed PMID: 32265272; PubMed Central PMCID: PMC7325432.

Swenson SA, Moore CM, Marcero JR, Medlock AE, Reddi AR, Khalimonchuk O. From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme. Cells. 2020 Feb 29;9(3). doi: 10.3390/cells9030579. Review. PubMed PMID: 32121449; PubMed Central PMCID: PMC7140478.

Piel RB 3rd, Dailey HA Jr, Medlock AE. The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution. Mol Genet Metab. 2019 Nov;128(3):198-203. doi: 10.1016/j.ymgme.2019.01.006. Epub 2019 Jan 17. Review. PubMed PMID: 30709775; PubMed Central PMCID: PMC6640082.

Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr. Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Blood. 2018 Sep 6;132(10):987-998. doi: 10.1182/blood-2018-01-829036. Epub 2018 Jul 10. PubMed PMID: 29991557; PubMed Central PMCID: PMC6128084.

Cahill MA, Medlock AE. Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands. J Steroid Biochem Mol Biol. 2017 Jul;171:11-33. doi: 10.1016/j.jsbmb.2016.12.020. Epub 2017 Jan 16. Review. PubMed PMID: 28104494.

Heme Biosynthesis, A. E. Medlock and H.A. Dailey, chapter in Metalloprotein Active Site Assembly, 1st Ed., ed. Robert A. Scott and Michael K. Johnson (2017), Wiley.

Piel RB 3rd, Shiferaw MT, Vashisht AA, Marcero JR, Praissman JL, Phillips JD, Wohlschlegel JA, Medlock AE. A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Biochemistry. 2016 Sep 20;55(37):5204-17. doi: 10.1021/acs.biochem.6b00756. Epub 2016 Sep 9. PubMed PMID: 27599036; PubMed Central PMCID: PMC5278647.

Medlock AE, Shiferaw MT, Marcero JR, Vashisht AA, Wohlschlegel JA, Phillips JD, Dailey HA. Identification of the Mitochondrial Heme Metabolism Complex. PLoS One. 2015;10(8):e0135896. doi: 10.1371/journal.pone.0135896. eCollection 2015. PubMed PMID: 26287972; PubMed Central PMCID: PMC4545792.

Managing Micronutrient Nutrition: The Vitamin B12 Exemplar, A. Medlock , G. Crites , J. Stowe, MedEdPORTAL 2014. Available from:www.mededportal.org/publication/9771

Just-in-Time Teaching (JiTT): An Active Learning Pedagogy to Study Concepts in Cell Biology, V. T. Gaddy and A. E. Medlock, Med Sci Educ 2013, 23 (4), 664-665.

Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 2012 Nov 22;491(7425):608-12. doi: 10.1038/nature11536. Epub 2012 Nov 7. PubMed PMID: 23135403; PubMed Central PMCID: PMC3504625.

Medlock AE, Najahi-Missaoui W, Ross TA, Dailey TA, Burch J, O'Brien JR, Lanzilotta WN, Dailey HA. Identification and characterization of solvent-filled channels in human ferrochelatase. Biochemistry. 2012 Jul 10;51(27):5422-33. doi: 10.1021/bi300598g. Epub 2012 Jun 28. PubMed PMID: 22712763; PubMed Central PMCID: PMC3448031.

Porphyrin Metabolism, M. Shepherd, A. E. Medlock and H. A. Dailey, chapter in Encyclopedia of Biological Chemistry, 2nd Ed., ed. Lennarz, W., Lane, D. M. and Perkins, M. (2013), Elsevier, 544-549.

Medlock AE, Carter M, Dailey TA, Dailey HA, Lanzilotta WN. Product release rather than chelation determines metal specificity for ferrochelatase. J Mol Biol. 2009 Oct 23;393(2):308-19. doi: 10.1016/j.jmb.2009.08.042. Epub 2009 Aug 22. PubMed PMID: 19703464; PubMed Central PMCID: PMC2771925.

Regulation of Mammalian Heme Biosynthesis, A. E. Medlock and H. A. Dailey, chapter in Tetrapyrroles: Birth, Life and Death, ed. Warren, M. J. and Smith, A.G. 2009, Landes Bioscience and Springer Science + Business Media, 116-127.

Medlock AE, Dailey TA, Ross TA, Dailey HA, Lanzilotta WN. A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase. J Mol Biol. 2007 Nov 2;373(4):1006-16. doi: 10.1016/j.jmb.2007.08.040. Epub 2007 Aug 23. PubMed PMID: 17884090; PubMed Central PMCID: PMC2083577.

Dailey HA, Wu CK, Horanyi P, Medlock AE, Najahi-Missaoui W, Burden AE, Dailey TA, Rose J. Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis. Biochemistry. 2007 Jul 10;46(27):7973-9. doi: 10.1021/bi700151f. Epub 2007 Jun 14. PubMed PMID: 17567154; PubMed Central PMCID: PMC2424199.

Medlock A, Swartz L, Dailey TA, Dailey HA, Lanzilotta WN. Substrate interactions with human ferrochelatase. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1789-93. doi: 10.1073/pnas.0606144104. Epub 2007 Jan 29. PubMed PMID: 17261801; PubMed Central PMCID: PMC1794275.

Pondarré C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, Deck KM, McDonald A, Han AP, Medlock A, Kutok JL, Anderson SA, Eisenstein RS, Fleming MD. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet. 2006 Mar 15;15(6):953-64. doi: 10.1093/hmg/ddl012. Epub 2006 Feb 8. PubMed PMID: 16467350.

Medlock AE, Meissner PN, Davidson BP, Corrigall AV, Dailey HA. A mouse model for South African (R59W) variegate porphyria: construction and initial characterization. Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):71-8. PubMed PMID: 11929050.

Dailey HA, Dailey TA, Wu CK, Medlock AE, Wang KF, Rose JP, Wang BC. Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters. Cell Mol Life Sci. 2000 Dec;57(13-14):1909-26. doi: 10.1007/pl00000672. Review. PubMed PMID: 11215517.

Medlock AE, Dailey HA. Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases. Biochemistry. 2000 Jun 27;39(25):7461-7. doi: 10.1021/bi000134p. PubMed PMID: 10858295.

Resonance Raman Spectra of Ferrochelatase Reveal Porphyrin Distortion upon Metal Binding, M. E. Blackwood, Jr. T. S. Rush, III, A. Medlock, H. A. Dailey, and T. G. Spiro J Am Chem Soc 1997, 119, 12170-12174.

Medlock AE, Dailey HA. Human coproporphyrinogen oxidase is not a metalloprotein. J Biol Chem. 1996 Dec 20;271(51):32507-10. doi: 10.1074/jbc.271.51.32507. PubMed PMID: 8955072.