Publications

 

2017

Lechtreck, K.-F. (2017). Dynein in Intraflagellar Transport. In: Handbook of Dynein. Hirose, K. (Ed.).  In press.

Snouffer, A., Brown, D., Le, H., Walsh, J., Lupu, F., Norman, R., Lechtreck, K.-F., Ko, H.W., and Eggenschwiler, J. (2017). Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice. PLOS Genetics 13:e1006912

Wingfield, J.L., Mengoni, I., Bomberger, H., Jiang, Y.-Y., Walsh, J.D., Brown, J.M., Picariello, T., Cochran, C.A., Zhu, B., Pan, J., Eggenschwiler, J., Gaertig, J., Witman, G.B., Kner, P., and Lechtreck, K.-F. (2017). IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium. Elife. May 31.

Lechtreck K.-.F, Van De Weghe J.C., Harris J.A., Liu P. (2017). Protein transport in growing and steady-state cilia. Traffic 18: 277-286.

 

2016

Lechtreck, K.-F. (2016). Methods for Studying Movement of Molecules Within Cilia. Methods of Molecular Biology: Cilia. Eds.: S.T. Christensen & P. Satir. Volume 1454:83-96

Harris, J.A., Liu, Y., Yang, P., Kner, P., and Lechtreck, K.-F. (2016). Single particle imaging reveals IFT-independent transport and accumulation of EB1 in Chlamydomonas flagella. Molecular Biology of the Cell 27: 295-307.

Kubo T, Brown JM, Bellve K, Craige B, Craft JM, Fogarty K, Lechtreck KF, Witman GB. (2016). Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin. Journal of Cell Science 129:2106-19.

Tran, P.V. and Lechtreck, K.-F. (2016). An age of enlightenment for cilia: The FASEB Summer Research Conference on the “Biology of Cilia and Flagella”. Meeting Report. Developmental Biology 409:319-28

 

2015

Lechtreck, K.-F. (2015) IFT-cargo interactions and protein transport in cilia. Trends in Biochemical Science 40:765-778.

Jiang, Y.-Y., Lechtreck, K.-F. and Gaertig, J. (2015). Total Internal Reflection Fluorescence Microscopy of Intraflagellar Transport in Tetrahymena thermophila. In: Methods in Cilia & Flagella, W.F. Marshall (Ed.) Elsevier Science and Technology. Vol 127; p. 223-237.

Vasudevan, K.K., Jiang Y.-Y., Lechtreck, K.-F., Kushida, Y., Alford, L.M., Sale, W.S., Hennessey, T. and Gaertig, J. (2015). Kinesin-13 regulates the quantity and quality of tubulin inside cilia. Mol. Biol Cell 26:478-94

Craft, J.M., Harris, J.A., Hyman, S., Kner, P., and Lechtreck, K.-F. (2015). Tubulin Transport by IFT is Upregulated during Ciliary Growth by a Cilium-autonomous Mechanism. J. Cell Biol. 208:223-237. (see also JCB biosights video)

 

2014

Awata, J.,Takada, S., Standley, C., Lechtreck, K.-F., Bellvé, K.D., Pazour, G.J., Fogarty, K.E., and Witman, G.B. (2014). Nephrocystin-4 controls ciliary trafficking of membrane and large soluble proteins at the transition zone. J. Cell Sci. 127:4714–4727.

Bhogaraju, S., Weber, K., Engel, B.D., Lechtreck, K.-F. and Lorentzen, E. (2014) Getting tubulin to the tip of the cilium: One IFT train, many different tubulin cargo-binding sites? Bioassays.

Lechtreck, K.F. (2014) Chlamydomonas reinhardtii as a model for flagellar assembly. Perspectives in Phycology 1: 41 - 51 (Invited review for inaugural issue). (Request reprint)

 

2013

Wren, K., Craft, J.M., Tritschler, D., Schauer, A., Patel,, D.K., Smith E.F., Porter, M.E., Kner, P., and Lechtreck, K.-F. (2013). A differential cargo loading model of ciliary length regulation by IFT. Current Biology 23, 2463–2471.

Lechtreck, K.-F., Gould, T.J., and Witman, G.B. (2013). Flagellar central pair assembly in Chlamydomonas reinhardtii. Cilia 2,15.

Lechtreck, K.-F., Brown, J.M., Sampaio, J.L., Shevchenko, A., Evans, J.E. and Witman, G.B. (2013). Cycling of the signaling protein Phospholipase D through cilia requires the BBSome only for the export phase. Journal of Cell Biology 201, 249-61.

Ludington, W.B., Wemmer, K.A., Lechtreck, K.-F., Witman, G.B., and Marshall, W.F. (2013). Avalanche-like behavior in ciliary import. PNAS 110, 3925-3930.

Lechtreck, K.-F. (2013). Visualizing IFT in Chlamydomonas flagella. Methods in Enzymology, 524, 265-284.

 

pre UGA (selected)

Craige, B., Tsao, C.-C., Diener, D.R., Hou, Y., Lechtreck, K.-F., Rosenbaum J.L., and Witman, G.B. (2010). CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content. Journal of Cell Biology 190, 927-940.

Lechtreck, K.-F., Johnson, E.C., Sakai, T., Cochran, D., Ballif, B.A., Rush, J., Pazour, G.J., Ikebe, M., Witman, G.B. (2009). The Chlamydomonas BBSome is an IFT cargo required for export of specific signaling proteins from flagella. Journal of Cell Biology 187, 1117-1132.

Lechtreck , K.-F., Luro, S., and Witman, G.B. (2009). HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B. Cell Motil Cytoskel. 66, 469-82.

Lechtreck, K.-F., Delmotte, P., Robinson, M.L., Sanderson, M.J., and Witman, G.B. (2008). Mutations in Hydin impair ciliary motility in mice. Journal of Cell Biology 180, 633-643.

Lechtreck, K.-F. and Witman, G.B. (2007). Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility. Journal of Cell Biology 176, 473-482.

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