• Ferrochelatase Tunnel Images

Publications

Publications

Pubmed Bibliogrpahy URL.
https://www.ncbi.nlm.nih.gov/sites/myncbi/amy.medlock.1/bibliography/42526867/public/?sort=date&direction=descending

Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands, M. A. Cahill and A. E. Medlock, Journal of Steroid Biochemistry and Molecular Biology, 2017, 171, 11-33.

Heme Biosynthesis, A. E. Medlock and H.A. Dailey, chapter in Metalloprotein Active Site Assembly, 1st Ed., ed. Robert A. Scott and Michael K. Johnson (2017), Wiley.

A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase, R. B. Piel III, M. T. Shiferaw, A. A. Vashisht, J. Marcero, J. Praissman, J. Phillips, J. Wohlschlegel and A. E. Medlock, Biochemistry, 2016, 55, 5204-5217.

Identification of the Mitochondrial Heme Metabolism Complex, A. E. Medlock, M. T. Shiferaw, Jason R. Marcero, Ajay A. Vashisht, James A. Wohlschlegel, John D. Phillips, and Harry A. Dailey, PLoS One, 2015, 10(8):e0135896.

Managing Micronutrient Nutrition: The Vitamin B12 Exemplar, A. Medlock , G. Crites , J. Stowe, MedEdPORTAL 2014. Available from:www.mededportal.org/publication/9771

Just-in-Time Teaching (JiTT): An Active Learning Pedagogy to Study Concepts in Cell Biology, V. T. Gaddy and A. E. Medlock, Med Sci Educ 2013, 23 (4), 664-665.

Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts, D. I. Shah, N. Takahashi-Makise, J. D. Cooney, L. Li, I. J. Schultz, E. L. Pierce, A. Narla, S. M. Hattangadi, A. E. Medlock, N. B. Langer, T. A. Dailey, S. N. Hurst, D. Faccenda, J. M. Wiwczar, S. K. Heggers, G. Vogin, W. Chen, C. Chen, D. R. Campagna, C. Brugnara, Y. Zhou, B. L. Elbert, N. N. Danial, M. D. Fleming, D. M. Ward, M. Campanella, , H. A. Dailey, J. Kaplan, and B. H. Paw, Nature 2012, 491(7425), 608-612.

Identification and Characterization of Solvent-Filled Channels in Human Ferrochelatase, A. E. Medlock,W. Najahi-Missaoui, T. A. Ross, T. A. Dailey, J. Burch, J. R. O’Brien, W. N. Lanzilotta and H. A. Dailey, Biochemistry 2012, 51 (27), 5422-5433.

Porphyrin Metabolism, M. Shepherd, A. E. Medlock and H. A. Dailey, chapter in Encyclopedia of Biological Chemistry, 2nd Ed., ed. Lennarz, W., Lane, D. M. and Perkins, M. (2013), Elsevier, 544-549.

Product Release Rather than Chelation Determines Metal Specificity for Ferrochelatase, A. E. Medlock, M. Carter, T. A. Dailey, H. A. Dailey, and W. N. Lanzilotta, J Mol Biol 2009, 393(2), 308-319.

Regulation of Mammalian Heme Biosynthesis, A. E. Medlock and H. A. Dailey, chapter in Tetrapyrroles: Birth, Life and Death, ed. Warren, M. J. and Smith, A.G. 2009, Landes Bioscience and Springer Science + Business Media, 116-127.

A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase, A. E. Medlock, T. A. Dailey, T. A. Ross, H. A Dailey and W. N. Lanzilotta J Mol Biol 2007, 373(4) 1006-1016.

Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis, H. A. Dailey, C. -K. Wu, P. Horanyi, A. E. Medlock, W. Najahi-Missaoui, A. E. Burden, T. A. Dailey and J. Rose Biochemistry 2007, 46(27), 7973-7979.

Substrate interactions with human ferrochelatase, A. Medlock, L. Swartz, T. A. Dailey, H. A. Dailey, and W. N. Lanzilotta Proc Natl Acad Sci U S A 2007, 104(6), 1789-1793.

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis, C. Pondarre, B. B. Antiochos, D. R. Campagna, S. L Clarke, E. L. Greer, K. M. Deck, A. McDonald, A. P. Han, A. Medlock, J. L. Kutok, S. A. Anderson, R. S. Eisenstein and M. D. Fleming Hum Mol Genet 2006, 15(6), 953-964.

A Mouse Model for South African (R59W) variegate porphyria:  Construction and initial characterization, A. E. Medlock, P. N. Meissner, B. P. Davidson, A. V. Corrigall and H. A. Dailey Cell Mol Biol 2002, 48, 71-78.

Ferrochelatase at the millennium: structures, mechanisms, and [2Fe-2S] cluster, H. A. Dailey, T. A. Dailey, C.- K. Wu, A. E. Medlock and K.-F. Wang Cell Mol Life Sci 2000, 57,1909-1926.

Examination of the Activity of Carboxyl-Terminal Chimeric Constructs of Human and Yeast Ferrochelatases, A. E. Medlock and H. A. Dailey Biochemistry 2000, 39, 7461-7467.

Resonance Raman Spectra of Ferrochelatase Reveal Porphyrin Distortion upon Metal Binding, M. E. Blackwood, Jr. T. S. Rush, III, A. Medlock, H. A. Dailey, and T. G. Spiro J Am Chem Soc 1997, 119, 12170-12174.

Human Coproporphyrinogen Oxidase Is Not a Metalloprotein, A. E. Medlock and H. A. Dailey J Biol Chem 1996, 271, 32507-32510.