Link for PubMed - https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40767526/?sort=date&direction=descending

Link for GRA - http://gra.org/scholar/89/Dennis_Kyle.html

Publications (since 2010)

Obaldia, N., Milhous, W. K., & Kyle, D. E. (2018). Reversal of chloroquine resistance of Plasmodium vivax in Aotus monkeys.. Antimicrobial agents and chemotherapy. doi:10.1128/aac.00582-18

Roth, A., Maher, S. P., Conway, A. J., Ubalee, R., Chaumeau, V., Andolina, C., . . . Adams, J. H. (2018). Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum. Nature Communications9(1). doi:10.1038/s41467-018-04817-1

Roth, A., Maher, S. P., Conway, A. J., Ubalee, R., Chaumeau, V., Andolina, C., . . . Adams, J. H. (2018). A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum. Nature Communications9(1). doi:10.1038/s41467-018-04221-9

Siegel, S. V., Rivero, A. V., Oberstaller, J., Colon, B. L., de Buron, I., & Kyle, D. E. (2018). Blood flukes Cardicola parvus and C. laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae). Parasitology International67(2), 150-158. doi:10.1016/j.parint.2017.10.012

Duvalsaint, M., & Kyle, D. E. (2018). Phytohormones, Isoprenoids, and Role of the Apicoplast in Recovery from Dihydroartemisinin-Induced Dormancy of Plasmodium falciparum.. Antimicrob Agents Chemother62(3). doi:10.1128/AAC.01771-17

Thomas, S. A. L., von Salm, J. L., Clark, S., Ferlita, S., Nemani, P., Azhari, A., . . . Baker, B. J. (2018). Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima.. Journal of natural products,81(1), 117-123. doi:10.1021/acs.jnatprod.7b00732

Neelarapu, R., Maignan, J. R., Lichorowic, C. L., Monastyrskyi, A., Mutka, T. S., LaCrue, A. N., . . . Manetsch, R. (2018). Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1 H )-Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies. Journal of Medicinal Chemistry61(4), 1450-1473. doi:10.1021/acs.jmedchem.7b00738

Siegel, S., Rivero, A., Adapa, S., Wang, C., Manetsch, R., Jiang, R. H. Y., & Kyle, D. E. (2017). Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in Plasmodium falciparum. BioRxiv. doi:10.1101/232033

McQueen, A., Blake, L. D., Azhari, A., Kemp, M. T., McGaha, T. W., Namelikonda, N., . . . Kyle, D. E. (2017). Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine. Bioorganic & Medicinal Chemistry Letters27(20), 4597-4600. doi:10.1016/j.bmcl.2017.09.030

Kanwar, A., Eduful, B. J., Barbeto, L., Carletti Bonomo, P., Lemus, A., Vesely, B. A., . . . Leahy, J. W. (2017). Synthesis and Activity of a New Series of Antileishmanial Agents. ACS Medicinal Chemistry Letters8(8), 797-801. doi:10.1021/acsmedchemlett.7b00039

Kosaisavee, V., Suwanarusk, R., Chua, A. C. Y., Kyle, D. E., Malleret, B., Zhang, R., . . . Russell, B. (2017). Strict tropism for CD71 +  /CD234  + human reticulocytes limits the zoonotic potential of  Plasmodium cynomolgi  . Blood130(11), 1357-1363. doi:10.1182/blood-2017-02-764787

Wirjanata, G., Handayuni, I., Prayoga, P., Leonardo, L., Apriyanti, D., Trianty, L., . . . Marfurt, J. (2017). Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes. Antimicrobial Agents and Chemotherapy61(8), e00355-17. doi:10.1128/AAC.00355-17

Blake, L. D., Johnson, M. E., Siegel, S. V., McQueen, A., Iyamu, I. D., Shaikh, A. K., . . . Kyle, D. E. (2017). Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b  That Are Transmissible through Mosquitoes . Antimicrobial Agents and Chemotherapy61(8), e00689-17. doi:10.1128/AAC.00689-17

Giulianotti, M. A., Vesely, B. A., Azhari, A., Souza, A., LaVoi, T., Houghten, R. A., . . . Leahy, J. W. (2017). Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries. ACS Medicinal Chemistry Letters8(8), 802-807. doi:10.1021/acsmedchemlett.7b00045

Van Voorhis, W. C., Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., . . . Willis, P. A. (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLOS PATHOGENS12(7). doi:10.1371/journal.ppat.1005763

Roberts, B. F., Iyamu, I. D., Lee, S., Lee, E., Ayong, L., Kyle, D. E., . . . Chakrabarti, D. (2016). Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages. International Journal for Parasitology: Drugs and Drug Resistance6(1), 85-92. doi:10.1016/j.ijpddr.2016.02.004

Waterman, C., Calcul, L., Beau, J., Ma, W. S., Lebar, M. D., von Salm, J. L., . . . Baker, B. J. (2016). Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Medicinal Research Reviews36(1), 144-168. doi:10.1002/med.21335

Maignan, J. R., Lichorowic, C. L., Giarrusso, J., Blake, L. D., Casandra, D., Mutka, T. S., . . . Manetsch, R. (2016). ICI 56,780 Optimization: Structure–Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1 H )-quinolones with Antimalarial Activity. Journal of Medicinal Chemistry59(14), 6943-6960. doi:10.1021/acs.jmedchem.6b00759

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., . . . Gilbert, I. H. (2016). Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature537(7618), 122. doi:10.1038/nature18280

Van Horn, K. S., Zhu, X., Pandharkar, T., Yang, S., Vesely, B., Vanaerschot, M., . . . Manetsch, R. (2016). Correction to Antileishmanial Activity of a Series of N 2 , N 4 -Disubstituted Quinazoline-2,4-diamines. Journal of Medicinal Chemistry59(2), 775. doi:10.1021/acs.jmedchem.5b00981

Obaldía III, N., Dow, G. S., Gerena, L., Kyle, D., Otero, W., Mantel, P. -Y., . . . Marti, M. (2016). Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Scientific Reports6(1). doi:10.1038/srep21216

Hott, A., Tucker, M. S., Casandra, D., Sparks, K., & Kyle, D. E. (2015). Fitness of artemisinin-resistant Plasmodium falciparum in vitro. Journal of Antimicrobial Chemotherapy70(10), 2787-2796. doi:10.1093/jac/dkv199

Pradhan, A., Siwo, G. H., Singh, N., Martens, B., Balu, B., Button-Simons, K. A., . . . Kyle, D. E. (2015). Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery. Scientific Reports5(1). doi:10.1038/srep15930

Rice, C. A., Colon, B. L., Alp, M., Göker, H., Boykin, D. W., & Kyle, D. E. (2015). Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens. Antimicrobial Agents and Chemotherapy59(4), 2037-2044. doi:10.1128/AAC.05122-14

Shao, C. -L., Linington, R. G., Balunas, M. J., Centeno, A., Boudreau, P., Zhang, C., . . . Gerwick, W. H. (2015). Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. The Journal of Organic Chemistry80(16), 7849-7855. doi:10.1021/acs.joc.5b01264

Hott, A., Casandra, D., Sparks, K. N., Morton, L. C., Castanares, G. -G., Rutter, A., & Kyle, D. E. (2015). Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes. Antimicrobial Agents and Chemotherapy59(6), 3156-3167. doi:10.1128/AAC.00197-15

Baragaña, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., . . . Gilbert, I. H. (2015). A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature522(7556), 315-320. doi:10.1038/nature14451

von Salm, J. L., Wilson, N. G., Vesely, B. A., Kyle, D. E., Cuce, J., & Baker, B. J. (2014). Shagenes A and B, New Tricyclic Sesquiterpenes Produced by an Undescribed Antarctic Octocoral. Organic Letters16(10), 2630-2633. doi:10.1021/ol500792x

Cross, R. M., Flanigan, D. L., Monastyrskyi, A., LaCrue, A. N., Sáenz, F. E., Maignan, J. R., . . . Manetsch, R. (2014). Orally Bioavailable 6-Chloro-7-methoxy-4(1 H )-quinolones Efficacious against Multiple Stages of Plasmodium. Journal of Medicinal Chemistry57(21), 8860-8879. doi:10.1021/jm500942v

Maher, S. P., Crouse, R. B., Conway, A. J., Bannister, E. C., Achyuta, A. K. H., Clark, A. Y., . . . Saadi, W. M. (2014). Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes. Biomedical Microdevices16(5), 727-736. doi:10.1007/s10544-014-9877-x

Rojas-Silva, P., Graziose, R., Vesely, B., Poulev, A., Mbeunkui, F., Grace, M. H., . . . Raskin, I. (2014). Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum. Pharmaceutical Biology52(3), 398-401. doi:10.3109/13880209.2013.837077

Chen, N., LaCrue, A. N., Teuscher, F., Waters, N. C., Gatton, M. L., Kyle, D. E., & Cheng, Q. (2014). Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy58(8), 4773-4781. doi:10.1128/AAC.02647-14

Henrich, P. P., O'Brien, C., Saenz, F. E., Cremers, S., Kyle, D. E., & Fidock, D. A. (2014). Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model. Antimicrobial Agents and Chemotherapy58(1), 183-195. doi:10.1128/AAC.01466-13

Van Horn, K. S., Zhu, X., Pandharkar, T., Yang, S., Vesely, B., Vanaerschot, M., . . . Manetsch, R. (2014). Antileishmanial Activity of a Series of N 2 , N 4 -Disubstituted Quinazoline-2,4-diamines. Journal of Medicinal Chemistry,57(12), 5141-5156. doi:10.1021/jm5000408

Monastyrskyi, A., Kyle, D. E., & Manetsch, R. (2014). 4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities.. Current topics in medicinal chemistry,14(14), 1693-1705. doi:10.2174/1568026614666140808124638

Jiménez-Díaz, M. B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A. M., Myrand-Lapierre, M. -E., . . . Guy, R. K. (2014). (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proceedings of the National Academy of Sciences111(50), E5455-E5462. doi:10.1073/pnas.1414221111

Calcul, L., Waterman, C., Ma, W., Lebar, M., Harter, C., Mutka, T., . . . Baker, B. (2013). Screening Mangrove Endophytic Fungi for Antimalarial Natural Products. Marine Drugs11(12), 5036-5050. doi:10.3390/md11125036

Srivastava, A., Sweat, J. M., Azizan, A., Vesely, B., & Kyle, D. E. (2013). Real-Time PCR to Quantify Leishmania donovani in Hamsters. Journal of Parasitology,99(1), 145-150. doi:10.1645/GE-3221.1

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I. P., Cross, R. M., Marfurt, J., . . . Riscoe, M. K. (2013). Quinolone-3-Diarylethers: A New Class of Antimalarial Drug. Science Translational Medicine5(177), 177ra37. doi:10.1126/scitranslmed.3005029

LaCrue, A. N., Saenz, F. E., Cross, R. M., Udenze, K. O., Monastyrskyi, A., Stein, S., . . . Kyle, D. E. (2013). 4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei. Antimicrobial Agents and Chemotherapy57(1), 417-424. doi:10.1128/AAC.00793-12

Saenz, F. E., LaCrue, A. N., Cross, R. M., Maignan, J. R., Udenze, K. O., Manetsch, R., & Kyle, D. E. (2013). 4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni. Antimicrobial Agents and Chemotherapy57(12), 6187-6195. doi:10.1128/AAC.00492-13

Teuscher, F., Chen, N., Kyle, D. E., Gatton, M. L., & Cheng, Q. (2012). Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum Lines In Vitro: Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition. Antimicrobial Agents and Chemotherapy56(1), 428-431. doi:10.1128/AAC.05456-11

Tucker, M. S., Mutka, T., Sparks, K., Patel, J., & Kyle, D. E. (2012). Phenotypic and Genotypic Analysis of In Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy56(1), 302-314. doi:10.1128/AAC.05540-11

Saenz, F. E., Mutka, T., Udenze, K., Oduola, A. M. J., & Kyle, D. E. (2012). Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro. Antimicrobial Agents and Chemotherapy56(9), 4685-4692. doi:10.1128/AAC.01061-12

Lowes, D., Pradhan, A., Iyer, L. V., Parman, T., Gow, J., Zhu, F., . . . Guy, R. K. (2012). Lead Optimization of Antimalarial Propafenone Analogues. Journal of Medicinal Chemistry55(13), 6087-6093. doi:10.1021/jm300286a

Zhang, Y., Clark, J. A., Connelly, M. C., Zhu, F., Min, J., Guiguemde, W. A., . . . Guy, R. K. (2012). Lead Optimization of 3-Carboxyl-4(1 H )-Quinolones to Deliver Orally Bioavailable Antimalarials. Journal of Medicinal Chemistry,55(9), 4205-4219. doi:10.1021/jm201642z

Beau, J., Mahid, N., Burda, W. N., Harrington, L., Shaw, L. N., Mutka, T., . . . Baker, B. J. (2012). Epigenetic Tailoring for the Production of Anti-Infective Cytosporones from the Marine Fungus Leucostoma persoonii. Marine Drugs10(12), 762-774. doi:10.3390/md10040762

Balunas, M. J., Grosso, M. F., Villa, F. A., Engene, N., McPhail, K. L., Tidgewell, K., . . . Gerwick, W. H. (2012). Coibacins A–D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins. Organic Letters14(15), 3878-3881. doi:10.1021/ol301607q

Cheng, Q., Kyle, D. E., & Gatton, M. L. (2012). Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?. International Journal for Parasitology: Drugs and Drug Resistance2, 249-255. doi:10.1016/j.ijpddr.2012.01.001

Kaewpongsri, S., Sriprawat, K., Suwanarusk, R., Kyle, D. E., Lek-Uthai, U., Leimanis, M., . . . Renia, L. (2011). The Presence of Leukocytes in Ex Vivo Assays Significantly Increases the 50-Percent Inhibitory Concentrations of Artesunate and Chloroquine against Plasmodium vivax and Plasmodium falciparum. Antimicrobial Agents and Chemotherapy55(3), 1300-1304. doi:10.1128/AAC.01103-10

Cross, R. M., Namelikonda, N. K., Mutka, T. S., Luong, L., Kyle, D. E., & Manetsch, R. (2011). Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1 H )-quinolones. Journal of Medicinal Chemistry54(24), 8321-8327. doi:10.1021/jm200718m

Dow, G. S., Gettayacamin, M., Hansukjariya, P., Imerbsin, R., Komcharoen, S., Sattabongkot, J., . . . Ohrt, C. (2011). Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta). Malaria Journal10(1), 212. doi:10.1186/1475-2875-10-212

Cross, R. M., Maignan, J. R., Mutka, T. S., Luong, L., Sargent, J., Kyle, D. E., & Manetsch, R. (2011). Optimization of 1,2,3,4-Tetrahydroacridin-9(10 H )-ones as Antimalarials Utilizing Structure–Activity and Structure–Property Relationships. Journal of Medicinal Chemistry54(13), 4399-4426. doi:10.1021/jm200015a

LaCrue, A. N., Scheel, M., Kennedy, K., Kumar, N., & Kyle, D. E. (2011). Effects of Artesunate on Parasite Recrudescence and Dormancy in the Rodent Malaria Model Plasmodium vinckei. PLoS ONE6(10), e26689. doi:10.1371/journal.pone.0026689

Lebar, M. D., Hahn, K. N., Mutka, T., Maignan, P., McClintock, J. B., Amsler, C. D., . . . Baker, B. J. (2011). CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorganic & Medicinal Chemistry19(19), 5756-5762. doi:10.1016/j.bmc.2011.08.033

Codd, A., Teuscher, F., Kyle, D. E., Cheng, Q., & Gatton, M. L. (2011). Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure. Malaria Journal10(1), 56. doi:10.1186/1475-2875-10-56

Zhu, X., Banerjee, M., Farhat, A. A., Reid, C., Pandharkar, T., Patrick, D. A., . . . Werbovetz, K. (2010). ANTILEISHMANIAL ACTIVITY OF NOVEL ARYLIMIDAMIDES. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENEVol. 83 (pp. 71). Atlanta, GA: AMER SOC TROP MED & HYGIENE. Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295819700239&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=bccb20a1f2d949998a887c45eb30dd98

Chavchich, M., Gerena, L., Peters, J., Chen, N., Cheng, Q., & Kyle, D. E. (2010). Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy54(6), 2455-2464. doi:10.1128/AAC.00947-09

Wang, M. Z., Zhu, X., Srivastava, A., Liu, Q., Sweat, J. M., Pandharkar, T., . . . Werbovetz, K. A. (2010). Novel Arylimidamides for Treatment of Visceral Leishmaniasis. Antimicrobial Agents and Chemotherapy54(6), 2507-2516. doi:10.1128/AAC.00250-10

Cross, R. M., Monastyrskyi, A., Mutka, T. S., Burrows, J. N., Kyle, D. E., & Manetsch, R. (2010). Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1 H )-quinolones with Antimalarial Activity. Journal of Medicinal Chemistry,53(19), 7076-7094. doi:10.1021/jm1007903

Balunas, M. J., Linington, R. G., Tidgewell, K., Fenner, A. M., Ureña, L. -D., Togna, G. D., . . . Gerwick, W. H. (2010). Dragonamide E, a Modified Linear Lipopeptide from Lyngbya majuscula with Antileishmanial Activity. Journal of Natural Products73(1), 60-66. doi:10.1021/np900622m

Chen, N., Chavchich, M., Peters, J. M., Kyle, D. E., Gatton, M. L., & Cheng, Q. (2010). Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro. Antimicrobial Agents and Chemotherapy54(8), 3395-3401. doi:10.1128/AAC.01421-09

Teuscher, F., Gatton, M., Chen, N., Peters, J., Kyle, D., & Cheng, Q. (2010). Artemisinin‐Induced Dormancy in Plasmodium falciparum : Duration, Recovery Rates, and Implications in Treatment Failure. The Journal of Infectious Diseases202(9), 1362-1368. doi:10.1086/656476

Sanchez, L. M., Lopez, D., Vesely, B. A., Della Togna, G., Gerwick, W. H., Kyle, D. E., & Linington, R. G. (2010). Almiramides A−C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds. Journal of Medicinal Chemistry,53(10), 4187-4197. doi:10.1021/jm100265s